Symptoms of an overdose include: agitation, blurred vision, change in consciousness, chest pain or discomfort, confusion, dark urine, diarrhea, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, fever, headache, inability to speak, loss of consciousness, muscle cramps, spasms, pain, or stiffness, nausea, nervousness, overactive reflexes, pain or discomfort in the arms, jaw, back, or neck, pale, clammy skin, palpitations, pounding in the ears, seeing, hearing, or feeling things that are not there, seizures, shivering, slow or fast heartbeat, slurred speech, sweating, talking or acting with excitement you cannot control, temporary blindness, thirst, trembling or shaking, trouble breathing, unusual tiredness or weakness, vomiting, or weakness in the arm or leg on one side of the body, sudden and severe
Once IGF-1 LR3 binds to IGF-1R on the sarcolemma, it triggers the PI3K/Akt/mTOR signaling cascade
Others noticed a dip, while many describe it as more nuanced
The experience with tirzepatide (Mounjaro/Zepbound) is instructive
doi: 10.1038/srep33251 30 TeedeHJKhomamiMBMormanRLavenJSEJohamAECostelloMFet al
